Flucytosine is a antifungal medication. It is specifically used, together with amphotericin B, for serious Candida infections and cryptococcosis.
It can also be used for the treatment of chromomycosis (chromoblastomycosis), if susceptible strains cause the infection.
Flucytosine must not be used as a sole agent in life threatening fungal infections due to relatively weak antifungal effects and fast development of resistance, but rather in combination with amphotericin B and/or azole antifungals such as fluconazole or itraconazole.
Minor infections such as candidal cystitis may be treated with flucytosine alone.
