Rifaximin is a antibiotic medication used to treat travelers diarrhea, irritable bowel syndrome, and hepatic encephalopathy.
Other uses include treatment of infectious diarrhea, small intestinal bacterial overgrowth, inflammatory bowel disease, and diverticular disease.
It is effective in treating small intestinal bacterial overgrowth regardless of whether it is associated with irritable bowel syndrome or not.
Rifaximin has also shown efficacy with rosacea, ocular rosacea which also presents as dry eyes for patients with co-occurrence with small intestinal bacterial overgrowth (SIBO).